Figure 3

Modulation of neutrophil ribosomal/TRP53 pathway impacts the ability of Salmonella to infect and proliferate intracellularly. Flow cytometry for neutrophils left untreated at zero hours (column T0) or pre-treated for four (column T4) or eight hours (column T8) with RPL39 siRNA (row A), RPL9 siRNA (row B), TRP53 inhibitor (row C), and TRP53 activator (row D) and then infected with GFP fluorescent labeled Salmonella. Fluorescence intensity represents bacterial replication. Line graphs show the overlay of three replicate experiments.